WebJul 1, 2024 · FIP200 (FAK family interacting protein of 200 kDa) was identified as an essential autophagy gene, which was shown to play a key role in breast cancer development and progression. By crossing Tsc1f/f, Scl-Cre mice with Fip200f/f mice, we generated Tsc1/Fip200 double cKO mice. WebOct 2, 2024 · Abstract. Renal angiomyolipoma (AML) and cysts are seen in 70-80% of patients with the human tumor suppressor gene syndrome tuberous sclerosis complex …
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WebFeb 1, 2024 · TSC1-conditional knockout (DMP1-Cre+ ; TSC1f/f , hereafter CKO) mice and littermate control (DMP1-Cre- ; TSC1f/f , hereafter WT) mice were generated. H&E … WebmTORC1 is a key regulator of cell metabolism and lymphocyte proliferation. mTORC1 is inhibited by the tuberous sclerosis complex (TSC), a heterodimer of TSC1 and TSC2. Deletion of either genes results in robust activation of mTORC1. Mature B cells
Webgenotype/variation: TSC1f/f / p62f/f mice AlbCre positive - Specific deletion of TSC1 and p62 in hepatocytes Growth protocol p62F/F and Tsc1 F/F mice (Mori et al., 2009; Muller et al., … WebTuberous sclerosis complex (TSC) is a genetically determined hamartomatous neurocutaneous disease with high phenotypic variability. TSC is characterized by widespread hamartomas and benign, or rarely malignant, neoplasms distributed in several organs throughout the body, especially in the brain, skin, retina, kidney, heart, and lung. …
WebMay 30, 2013 · Caroline F. Bruinsma MSc. Department of Neuroscience, Erasmus University Medical Center, Rotterdam, the Netherlands. ENCORE Expertise Center for … WebJul 7, 2024 · GEO help: Mouse over screen elements for information. p62/SQSTM1 is a ubiquitin-binding autophagy receptor and signaling protein that accumulates in …
WebWe allowed Tsc1f/f; Rosa26-CreERT2 glioma cells to form spheres in culture and then added 4-hydroxytamoxifen (4-OHT) to delete the Tsc1 gene. First, we confirmed that 4-OHT efficiently induced Tsc1 deletion in these sphere cells, as evidenced by the disappearance of TSC1 protein from lysates of sphere cells that had been cultured with 4-OHT ( Fig. 2 A ).
WebOn the other hand, Tsc1 deficiency in the Dermo1 lineage did not produce detectable phenotypical changes in the kidney. Cyst formation in Prx1-Cre; Tsc1f/f and Osx-Cre; … granite ware r covered oval roasterWebThe resultant conditional Tsc1f/f;Cre⫹/⫺ an- which time, whole body and organ specific FDG uptake imals (designated as Tsc1c⫺/⫺) were viable and fertile was quantified. Results were based on the ratio of FDG Figure 6. Liver-specific activation of mTORC1 in Tsc1c⫺/⫺ mice. graniteware roaster dishwasherWebDec 12, 2014 · genotype: Tsc1f/f, Mx1-Cre+ (Cre positive cKO): KO LSK 1, KO LSK 2, KO LSK 3, KO LSK 4 biological replicate: WT LSK 1, WT LSK 2, WT LSK 3, WT LSK 4 biological replicate: KO LSK 1, KO LSK 2, KO LSK 3, KO LSK 4 : Contributor(s) Ye P, Liu Y, Chen C, Tang F, Wu Q, Wang X, Liu C, Liu X, Liu R, Liu Y, Zheng P: Citation missing: Has this study been ... chinook capabilitiesWebNeurofilament light polypeptide, also known as neurofilament light chain, abbreviated to NF-L or Nfl and with the HGNC name NEFL is a member of the intermediate filament protein family. This protein family consists of over 50 human proteins divided into 5 major classes, the Class I and II keratins, Class III vimentin, GFAP, desmin and the others, the Class IV … granite ware replacement partsWebOverall design: p62F/F and Tsc1 F/F mice (Mori et al., 2009; Muller et al., 2013) were backcrossed to C57BL/6 mice for at least 7 generations, and then bred with Alb-Cre transgenic mice (also on C57BL/6 background) to generate p62F/F; Alb-Cre (p62Δhep) and Tsc1F/F; Alb-Cre (Tsc1Δhep)mice, respectively. p62Δhep mice were crossed to Tsc1Δhep ... graniteware roaster chicken thighWebJan 12, 2024 · CD11c Cre, Tsc1 f/f, Raptor f/f, OT-I and OT-II mice were purchased from Jackson Laboratories (Bar Harbor, ME, USA). All used mice have been backcrossed with … chinook cardiologyWebTSC1f/f OT1 and mice mice had been extracted from The Jackson Lab, while Compact disc4Cre mice had been extracted from Taconic Farms. Mice had been housed under specific-pathogen-free circumstances and found in compliance with Country wide Institutes of Health guidelines. graniteware roaster pan