Thiopental distribution
WebDrug Distribution to Tissues. After a drug enters the systemic circulation, it is distributed to the body’s tissues. Distribution is generally uneven because of differences in blood … WebAs with other highly lipid-soluble drugs, the terminal disposition and steady-state volumes of distribution for thiopental are three to four times greater than normal; as a result, the elimination of thiopental can be expected to be delayed.
Thiopental distribution
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WebAfter a drug enters the systemic circulation, it is distributed to the body’s tissues. Distribution is generally uneven because of differences in blood perfusion, tissue binding (eg, because of lipid content), regional pH, and permeability of cell membranes. Web925 rows · Thiopental is a barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure. Generic Name. Thiopental. DrugBank Accession …
WebAbstract. Thiopental is an ultra short-acting barbiturate which remains the standard against which other induction agents are judged; it is also indicated for the therapy of brain … WebDistribution is a necessary step for the active molecules to reach their pharmacological target. The extent of distribution determines the amount of drug to be administered in order to acheive suitable concentration levels. Distribution also affects the drug’s half-life. For some drugs, the distribution is the process that puts an end to an ...
WebJan 21, 2011 · Sodium thiopental is an important and medically necessary anesthetic agent that has been used for years to induce anesthesia in patients undergoing surgical procedures. ... but we also do not condone using the issue as the basis to place undue burdens on the distribution of this critical drug to the United States.
central ohio golf courses publicWebMost sedative-hypnotic drugs are lipid-soluble and are absorbed well from the gastrointestinal tract, with good distribution to the brain. Drugs with the highest lipid solubility (eg, thiopental) enter the CNS rapidly and can be used as induction agents in anesthesia.The CNS effects of thiopental are terminated by rapid redistribution of the … central ohio golf league openingsWebDexmedetomidine significantly decreased distribution volumes (V2, V3, and Vdss) and distribution clearances (Cl12 and Cl13) of thiopental. Conclusions: Dexmedetomidine reduces thiopental distribution, most probably by decreasing cardiac output and regional blood flow. Publication types Clinical Trial central ohio golf course mapWebOct 1, 2004 · Thiopental 7.5 mg kg −1 IBW TBW Midazolam TBW for initial dose IBW for continuous dose Vecuronium IBW Atracurium TBW Initial dose 0.15 mg/kg–2.3 mg/10 kg … buy juice filling lineWebMay 9, 2008 · The model also predicts a decrease in whole body distribution clearance with increasing residence time dispersion $${({\rm RD}_{\rm D}^2)}$$ . ... Weiss M, Krejcie TC, Avram MJ (2007) A minimal physiological model of thiopental distribution kinetics based on a multiple indicator approach. Drug Metab Disp 35: 1525–1532. central ohio golf course directoryWebThiopental—distribution. Protein binding—thiopental. Model, mathematical—thiopental distribution. The authors greatly appreciate helpful discussions with Dr. James A. Gillette … central ohio greyhound rescueWebMar 31, 2024 · Elimination and half-life of thiopental in the T1 group compared to the control and T2 groups showed a significant decrease and increase, respectively. In addition, the distribution volume of... buy juice beauty