Phosphopantetheine attachment site

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August undefined, 2024

WebMay 28, 2010 · The amino acid sequence of NDRG1/Cap43 has been reported to bear a phosphopantetheine attachment site, an α/β hydrolase fold and three tandem repeats [15], [19], as well as a few sites that are phosphorylated by SGK [20] (Fig. 1 A). Western blotting revealed that NDRG1/Cap43 protein had several bands with different mobilities, including … WebJan 10, 2024 · To obtain active CAR enzyme, a phosphopantetheine group must be attached covalently to a conserved serine in the PCP domain mediated by a suitable …

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WebAug 1, 2015 · Phosphopantetheine attachment site: Dieckmanna Cyclase (DKC) NADB-Rossmann: I3810-R4092: NAD(P)-binding motif: ORF3 (fumoA) encodes a cytochrome P450 monooxygenase which maybe catalyzes an unprecedented oxidative ring expansion of prefumosorinone A to form the 2-pyridone core of fumosorinone (Halo et al., 2008a). … WebACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Alternate IDs None Definition Binding an acyl group and presenting it for processing or … dynamic output in db

Phosphopantetheine - an overview ScienceDirect Topics

WebMar 21, 2024 · This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ( [ACP]) domain. ( FAS_HUMAN,P49327 ) (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. ( FAS_HUMAN,P49327 ) WebACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Definition: Interacting selectively and non-covalently with the attachment site of the … Web[0005] This invention relates to a method of treatment, in particular to a method for lowering blood pressue levels in mammals and to compounds and compositions for use in such me dynamic output range

US20050107308A1 Dipeptidyl peptidase IV inhibitors and their …

WebJul 17, 2024 · The PCP Ser702, which serves as the phosphopantetheine attachment site, is positioned 52 Å away from the bound AMP phosphate. By contrast, ... Webphosphopantetheine (or pantetheine 4' phosphate) (Ppant) prosthetic group that is covalently attached to an invariant serine residue of the CP domain. CP domains, typically … dynamic outdoors lake of the woodsWebPromotional Article Monitoring. Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database and email PDF copies to you promptly. dynamic outrigger splint

"Phosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). It is also present in formyltetrahydrofolate dehydrogenase. " - Phosphopantetheine attachment site

Phosphopantetheine attachment site

Genetic Evidences of Biosurfactant Production in Two

http://amigo.geneontology.org/amigo/term/GO:0000036 WebDownload scientific diagram Phylogenetic analysis of CARs. A) Domain organization of CAR sequences: adenylation domain (PFam PF00501), phosphopantetheine (PP) …

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WebPhosphopantetheine attachment site Provide feedback. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. WebPhylogenetic analysis of CARs. A) Domain organization of CAR sequences: adenylation domain (PFam PF00501), phosphopantetheine (PP) attachment site (PF00550), reductase domain (PF07793). B)...

Web4'-Phosphopantetheine C11H23N2O7PS CID 115254 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... WebDefinition: Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis. ID: GO:0000036 Synonyms: Articles referencing this term. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork ...

Webreductase; KR, ketoreductase; PP, phosphopantetheine attachment site (acyl carrier pro-tein of PKSs and thiolation of NPSs); AMP, adenylation; CON, condensation; HGT, horizon-tal … WebThe human NDUFAB1 protein contains a phosphopantetheine attachment site (DLGLDSLDQVEIIMAM), unique for acyl carrier proteins, and an EF-hand calcium binding domain (DIDAEKLMCPQEI). Transcripts of this gene are found in …

http://amigo.geneontology.org/amigo/term/GO:0000036

WebDec 6, 2013 · For NRPS, the domains are: adenylation (A), condensation (C), oxidation (Ox), thioesterase (Te) and 4-phosphopantetheine attachment site (PP). Figure 3. Alignment of the PKS/NRPS cluster at genomic coordinates of 3092397–3133943 in D. solani D s0432-1 with the two closest homologs in D. zeae Ech586 and T. turnerae T7901. The improved ... dynamic outputWebJan 6, 2024 · The Psc_Aza_B gene is predicted to encode a non-reducing polyketide synthase composed of ve modules: ACP transacylase, β-ketoacyl synthase, acyltransferase phosphopantetheine attachment site and ... dynamic output excelWebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier … Hei Sook Sul, ... Li Chen, in Progress in Nucleic Acid Research and Molecular … dynamic output track obstruction cardiac mriWebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty acids (FAs) (use ACPs) ( Scheme 23 ), polyketides (PKs) (use ACPs) ( Scheme … crystal view headlight restorerWebMar 23, 2024 · It has 12 putative transmembrane domains and intracellular N and C termini. SLC26A1 contains a sulfate transporter signature, a phosphopantetheine attachment site, … dynamic outdoors paWebSep 1, 2000 · Motifs I and III have been associated with ATP-binding and hydrolysis activities, respectively, since motif X contains a conserved serine to which a 4′-phosphopantetheine cofactor is very probably attached [ 3 ]. dynamic outflow obstructionWebPhosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for … dynamic outrigger extension splint