Ctgf in diabetic nephropathy
WebConnective tissue growth factor (CTGF) is a potent inducer of extracellular matrix accumulation. In diabetic nephropathy, CTGF expression is markedly upregulated both in podocytes and... WebOct 5, 2024 · Diabetic nephropathy (DN) is a critical diabetic complication. It is the major cause of end-stage renal disease (ESRD), and it cannot be easily relieved by strict glycemic control alone. 2, 3 Kidney fibrosis is the main pathologic change in DN, which eventually leads to ESRD. 4
Ctgf in diabetic nephropathy
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WebOct 5, 2024 · Kidney fibrosis is the main pathologic change in diabetic nephropathy (DN), which is the major cause of end-stage renal disease. ... Abbreviations: CTGF, connective tissue growth factor; DM, diabetic model; IHC, immunohistochemistry; PASM, periodic … WebJun 1, 2008 · CTGF is a secreted protein and can be detected in biological fluids. Previous small studies have reported that both urinary CTGF excretion and plasma CTGF levels …
WebNguyen TQ, Tarnow L, Jorsal A, Oliver N, Roestenberg P, Ito Y, Parving HH, Rossing P, Van Nieuwenhoven FA, Goldschmeding R: Plasma connective tissue growth factor is an … WebMar 27, 2024 · The diabetic chronic kidney disease (CKD) model in this study utilized uninephrectomy, high fat diet and one dose of streptozotocin which closely simulates human type 2 diabetic nephropathy. 25, 26 Male Sprague–Dawley rats (body weight 225–250 g, Charles River) were subjected to right nephrectomy under inhaled isoflurane anesthesia.
WebNov 16, 2004 · Connective tissue growth factor (CTGF, CCN2) CTGF is involved in extracellular matrix remodelling during development and in pathological conditions, and … Web2 hours ago · Magnetic Resonance Imaging Evaluation of Mineralocorticoid Receptor Antagonism in Diabetic Atherosclerosis (MAGMA) trial Presented at NKF Spring Clinical Meetings
WebExperimental Diabetic Nephropathy. In experimental diabetic nephropathy, increased intrarenal IGF-1 expression has been proposed to be a mediator of both the hypertrophic response and increased glomerular matrix production. ... Renal CTGF is overexpressed in kidney biopsies of patients with chronic glomerulopathies and tubulointerstitial damage ...
WebDiabetic nephropathy (DN) is the most common microvascular complication, which is expected to affect approximately 40–60% of diabetic individuals [5]. DN, also known as Diabetic Kidney Disease (DKD), is the deprivation of kidney function in patients with type 1 and type 2 diabetes [6]. In the absence of other renal disorders, DN is ... philip of macedon\u0027s sonWebDespite substantial progress in medical care, the morbidity rate of diabetic nephropathy (DN) remains high in patients with diabetes. Evidence suggests that connective tissue … truist bank social circle gaWebOct 1, 2001 · Immunohistochemistry detected CTGF protein in glomeruli of kidneys of non-obese diabetic mice 14 days after the onset of diabetes, and this was prominent by 70 days. CTGF protein is also present in glomeruli of human patients with diabetic nephropathy. No CTGF was detected in either normal murine or human glomeruli. truist bank smithfield ncWebJan 1, 2006 · CTGF is considered to be of particular interest to diabetic nephropathy because its expression is induced by high glucose and because it mediates transforming growth factor-β–dependent and … truist banks in memphis tnWeb糖尿病主要的微血管并发症之一是糖尿病肾病(Diabetic Nephropathy,DN)，其是引起终末期肾衰最常见的原因之一。 早期发现和诊断糖尿病肾病，寻找有效的防治方法具有重要意义。 philip of bavaria mary tudorWebConnective tissue growth factor (CTGF) is overexpressed in diabetic nephropathy (DN) and has therefore been implicated in its pathogenesis. The objective of the present study … philip of england titleWebApr 12, 2024 · Obesity-related glomerulopathy and diabetic nephropathy (DN) are serious complications to metabolic syndrome and diabetes. The purpose was to study effects of a fat, fructose and cholesterol-rich ... philip of ituraea