Chemokin cxcl13
WebCXCL12, CXCL13, and BAFF are markers of B cell activation in neuroinflammatory CNS disorders; 8,21 however, the mechanisms and consequences of elevated CXCL12 could be complicated due to multiple modulatory mechanisms, such as changes in expression, bioavailability, and post-translational modifications, as well as changes in its receptors … WebOct 10, 2024 · CXCL13: C-X-C motif chemokine ligand 13; NPY1R: Neuropeptide Y receptor Y1; CXCR2: C-X-C motif chemokine receptor 2. DISCUSSION The incidence of UC in China and other Asian countries is gradually increasing[ 19 ], but due to the complicated pathogenesis, accurate molecular biomarkers for diagnosing UC are still …
Chemokin cxcl13
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WebApr 12, 2024 · CXCL13, a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer cells, follicular dendritic cells, and human T follicular helper cells, was found to be linked to a number of ... WebAug 9, 2024 · CXCL13 (chemokine (C-X-C motif) ligand 13) is a B cell chemokine demonstrated to drive aggregate formation in tertiary lymphoid structures in mouse models of AAD , and CXCL12 has been demonstrated to be important in distinct lung inflammatory models . MMP-12 can modulate the activity of CXC chemokines by proteolytic processing .
WebMar 29, 2024 · The chemokine CXCL13 was the most upregulated cytokine across all idiopathic multicentric Castleman disease patients. Expression of CXCL13 was also significantly increased in iMCD lymph node germinal centers compared to controls in a … WebJul 22, 2024 · In this study we focus on the chemokine CXCL13, a small globular protein with a theoretical average mass of 10.31 kDa that has emerged as a key regulator of B-cell migration and lymphoid tissue ...
WebSep 12, 2024 · Introduction. C-X-C motif chemokine ligand 13 (CXCL13), also known as B cell attracting chemokine (BCA-1) or B lymphocyte chemoattractant (BLC), is a kind of chemokine that was originally identified in stromal cells of B cell follicles that regulates the homing of B cells and T cells subsets ().It is widely involved in the pathogenesis of …
WebCXCL13/BLC/BCA-1 is a constitutively expressed chemokine that plays an important role in B and T cell homing. It is expressed by salivary gland epithelium, dendritic cells, osteoclasts, and peritoneal macrophages. It …
WebThe lymphoid chemokine CXCL13 was selectively expressed in the B cell–rich areas, whereas CCL21 was exclusively produced in association with high endothelial cells in the T-cell areas of the foci. This pattern is highly reminiscent of the distribution of these … troy buchanan volleyballWebOct 8, 2009 · Furthermore, autocrine/paracrine activation of chemokine receptor-7 (CCR7) in HNSCC has been shown to mediate cell survival and metastasis. 30 Inflammatory cytokines such as IL-1β have been shown to induce CXCL13 production in differentiated osteoblasts 31 and human osteoblasts have been shown to express functional CXCR3 … troy bucko caltransWebNov 30, 2024 · CXCL13 chemokine is a novel player in multiple myeloma osteolytic microenvironment, M2 macrophage polarization, and tumor progression. Beider K, et al. J Hematol Oncol, 2024 Oct 10. PMID 36217194, Free PMC Article; CXCL13 is elevated in … troy buder naples flWebIn addition, other chemokines of this group including CXCL1, CXCL2, and CXCL7 had a significant increase compared to the control group (P≤0.05). However, ELR −, CXC chemokines such as CXCL4, CXCL13, and CXCL16 showed a smaller upregulation, while CXCL14 chemokine showed a significant decrease compared to the control group … troy buchanan hsWebSep 12, 2024 · CXCL13 is a chemokine that is widely involved in the pathogenesis of autoimmune diseases, tumors and inflammatory diseases. In this study, we investigate the role of CXCL13 in the pathogenesis of inflammatory bowel disease using both clinical specimens and animal models. We found that the serum CXCL13 concentration in IBD … troy buchanan high school bell scheduleWebOct 10, 2024 · CXCL13 may thus serve as a potential novel target in MM. Altogether, our findings suggest that bidirectional interactions of MΦ with MM tumor cells result in M2 MΦ polarization, CXCL13 induction, and subsequent OC activation, enhancing their ability to … troy buckridge seymour tnWebApr 12, 2024 · Additionally, statically analysis revealed that CXCL13 would be a best diagnostic value for determining the disease activity of SLE due to its moderate sensitivity (93.5%), specificity (95%), PPV (98.6%), NPV (79.2%) and OR (95%CI,250 … troy buell odfw